Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.

Ischemic cardiovascular events represent the leading cause of mortality and morbidity worldwide, and platelet aggregation and thrombus formation are the main effectors of acute arterial ischemic events. Although antiplatelet therapy is the cornerstone of antithrombotic treatment of ischemic cardiovascular disorders, available antiplatelet agents have less than satisfactory efficacy; thus, the ...

Aug 30, 2019 · Curcumin (chemically known as Diferuloylmethane) is the main active ingredient of the spice Turmeric (Curcuma Longa or JiangHuang) and is the main 'curcuminoid' compound (80% of curcuminoid weight is curcumin) alongside the other three curcuminoids known as demethoxycurcumin, bisdemethoxycurcumin, and cyclocurcumin. Curcuminoids in general are known to exist in the .

This review deliberates chemical composition as well as the most recent research findings on potential health benefits of ginger, including its antimicrobial, anti-inflammatory, blood pressure-lowering, cholesterol-lowering, antiplatelet aggregation, chemopreventive, .

• Published in: Botanics : Targets and Therapy · 2015Authors: K D P P Gunathilake · H P Vasantha RupasingheAffiliation: Dalhousie UniversityGet Price

Oxidant substances in cigarette smoke appear to be responsible for endothelial dysfunction. ... Prostacyclin is thought to be important in vascular homeostasis in that it is a local vasodilator and has antiplatelet aggregation effects.

Anti-oxidant activity Adding Petroselinum crispum leaves to the diet of 14people ... demonstrated strong antiplatelet aggregation effect. Aglycone flavonoids; keampferol, apigenin and cosmosiin are responsible compounds for this activity. However, it did not exert inhibition on

Quercetin (Que) is one of the most abundant and potent naturally occurring antioxidant. Que has been shown to exert many biological activities, including antiplatelet activity. Indeed, Que was shown to inhibit platelet aggregation in response to platelet agonists, such as ADP, collagen, thrombin and arachidonic acid. However, the lowest Que concentration that significantly inhibits agonist ...

• Published in: Food and Public Health · 2015Authors: Sapha MosawyAffiliation: Griffith UniversityAbout: Thrombosis · Thrombin · Quercetin · Platelet · Protein kinase A · FlavonolsGet Price

statins possess a rapid antiplatelet effect, ie, within 24 hours of administration. Also of relevance is the fact that it is not fully defined whether the antiplatelet property of statins is a pleiotro-pic effect and/or is dependent on low-density lipoprotein (LDL) lowering. Addressing these issues may .

Mar 13, 2011 · Hebbar et al. showed that high doses (0.3, 1.0 and 3.0 g/kg day) of resveratrol upregulate phase II and anti-oxidant genes in and male rats. Due to high rate of oxygen consumption and low levels of anti-oxidant defense enzymes, the brain and the heart are particularly vulnerable to hypoxic conditions and oxidative stress injuries.

Ginsenoside Rk1 (G-Rk1) is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG)) at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight databases to select in vivo and in vitro original studies that provided information about biological, pharmaceutical effects of G-Rk1 ...

In vitro anti-platelet aggregation activity of the extracts of Camellia sinensis Yadav Anu* and Mendhulkar V.D. Department of Botany, Institute of Science, 15, Madam Cama Road, Fort, Mumbai, Maharashtra- 400032 *Corresponding author Email: [email protected] Anti-platelet therapy is now appearing as an advanced tool in the treatment of

Moreover, wal hull extract displayed a distinct inhibitory effect on platelet aggregation in a dose-dependent manner without demonstrating cytotoxic effects on platelets. It seems that antiplatelet aggregation properties of wal hull extract are associated with its antioxidant nature.

• Cited by: 2Get Price

a dominant component of Dendrobium polyphenols, was reported to have antiplatelet aggregation, antimutagenicity, inducing apoptosis of cancer cells, and anti-inflammatory activity [19–22]; some polymers of bibenzyls or phenanthrenes showed inhibiting -glucosidase activity [23].

Anti- were potential to inhibit lipid peroxi- oxidant activity of tea polyphenols in dation, high anticholesterol activity we- vivo : evidence from animal studies. re potential to lower cholesterol level, J. Nutr. 133 : 3275S-3284S. antiplatelet activity were potential to Frum, Y and A.M. Viljoen. 2006.

Antiplatelet drugs are intended to prevent and/or reverse platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischaemic stroke. Platelets aggregate as haemostatic plugs at the site of vascular injury, whereby bleeding is limited or arrested in advance of plasma coagulation (Figure 1). This function of ...

No effect on saquinavir, rosiglitazone, or resveratrol was found in studies in healthy volunteers.44, 46, 47 Rutin has been shown to decrease the anticoagulant effect of warfarin, and limited studies suggest quercetin similarly exhibits antiplatelet aggregation activity.1, 29, 30, 41 Synergism with moclobemide and levodopa/carbidopa has been ...

Apr 19, 2016 · The EA fractions were also found to have the strongest antiplatelet activity compared with the methanol and hexane fraction. The results indicate that antiplatelet and antioxidant activities of citrus fruits are not only due to a particular group of compounds, but also due to a synergic effect of compounds with different characteristics.

The potential importance of the CD36 signaling pathway in atherothrombosis is supported by genetic studies showing protection from diet-induced atherosclerosis and thrombosis in mice lacking CD36 3 and human studies linking polymorphisms in the CD36 gene to levels of platelet CD36 expression and to risk of myocardial infarction (MI). 5

Patients with diabetes mellitus have an increased prevalence of vascular disease. Pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Platelets are intimately involved in the initiation and propagation of thrombosis. Evidence suggests that platelets from patients with type 2 diabetes have increased reactivity and baseline activation ...

Quercetin (Que) is one of the most abundant and potent naturally occurring antioxidant. Que has been shown to exert many biological activities, including antiplatelet activity. Indeed, Que was shown to inhibit platelet aggregation in response to platelet agonists, such as ADP, collagen, thrombin and arachidonic acid. However, the lowest Que concentration that significantly inhibits agonist ...

• Published in: Food and Public Health · 2015Authors: Sapha MosawyAffiliation: Griffith UniversityAbout: Thrombosis · Thrombin · Quercetin · Platelet · Protein kinase A · Flavonols[PDF]Get Price